Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, alcohol use. Simvastatin (zocor) package 10 mg 10 amount in a package.
Fibric acid derivatives or niacin at lipid-modifying dosagesat least 1 g daily Simvastatin is used alone or in combination with ezetimibe to decrease elevated serum total and LDL-cholesterol concentrations in patients with homozygous familial hypercholesterolemia as an adjunct to other lipid-lowering therapies e. Similar additive antilipemic effects were observed following therapy with the fixed-combination preparation containing simvastatin and ezetimibe; LDL-cholesterol was reduced by 45-60% following therapy with the fixed-combination preparation and by 33-49% following monotherapy with simvastatin 10-80 mg daily In another multicenter, what is a simvastatin medication study, the fixed-combination preparation containing 10 mg of ezetimibe and 20 mg of simvastatin was substantially more effective than doubling the dose of simvastatin e.
what is a simvastatin medication 20 to 40 mg The increased risk of adverse muscular effects should be considered what is a simvastatin medication simvastatin is used in combination with certain antilipemic agents e.
What is simvastatin used for uk Because HMG-CoA Atherosclerosis is a chronic process and the discontinuation of lipid-lowering drugs during pregnancy should have little impact on the outcome of long-term well-controlled studies of use with JUVISYNC during pregnancy; however, in rare statins.
In rat and rabbit animal reproduction studies, simvastatin revealed no childbearing age only when such patients are highly unlikely to conceive. ee WARNINGS or cholesterol derivatives are essential for fetal development.
J Clin Endocrinol Metab. Medline. Diamanti-Kandarakis E, Kouli CR, Bergiele AT, et al. 1999 Nov. 06-11. Medline. A survey of the polycystic ovary syndrome in the Greek island of Lesbos: hormonal and metabolic profile. what is simvastatin medicine
What is simvastatin medicine
Congestive heart failure CHF refers to a condition in which the heart loses the ability to function properly. Signs and symptoms of congestive heart failure may include fatigue, breathlessness, palpitations, angina, and edema. Physical examination, patient history, blood what is simvastatin medicine, and imaging tests are used to diagnose congestive heart failure.
Treatment of heart failure consists of lifestyle modification and taking medications to decrease fluid in the body and ease the what is simvastatin medicine on the heart. Learn dosage, side effects, and pregnancy safety information before taking this drug.
Heart disease, high blood pressure, diabetes, myocarditis, and cardiomyopathies are just a few potential causes of congestive heart failure. what is simvastatin medicine
Afety and efficacy of simvastatin have not what is simvastatin medicine evaluated in prepubertal girls or in children younger than 10 years of age. There were no detectable adverse effects on growth or sexual maturation in adolescent boys or girls or on duration of menstrual cycle in girls.
If therapy with simvastatin is considered, the manufacturer states that adolescent girls should be advised to use effective and appropriate contraceptive methods during therapy to reduce the likelihood of unintended pregnancy.Simvastatin product names pills:
- Actalipid 5 mg
- Docsimvasta 5 mg
- Doctiverine 10 mg
- Dosavastatin 40 mg
- Lipex 20 mg
- Lipinorm 20 mg
- Lodales 40 mg
- Normotherin 5 mg
- Simbastatin 5 mg
- Simcard 20 mg
- Simgal 40 mg
- Simvastatina 10 mg
- Simvastatinum 5 mg
- Simvofix 5 mg
- Simvor 40 mg
However, the relationship between simvastatin and these effects is unclear. For additional information on the role of simvastatin or other statins in the treatment of lipoprotein disorders, prevention of cardiovascular events, or other uses, see General Principles of Antilipemic Therapy and see Uses in the HMG-CoA Reductase Inhibitors General Statement.
Improvement in renal cholesterol emboli syndrome was reported in at least one patient who received simvastatin 10-40 mg daily for 3 months. Simvastatin also has been shown simvastatin 10 mg uses improve ejection fraction in cardiac transplant recipients.
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The incidence of myopathy, including rhabdomyolysis, was highest during the first year and then notably decreased during the subsequent years of treatment. In this trial, patients were carefully monitored and some interacting medicinal products were excluded. compared with 0% for patients on 20 mg/day.
The incidence of rhabdomyolysis defined as myopathy with a CK what is simvastatin used for uk times ULN inpatients on 80 mg/day was approximately 0.
Caution should be used when what is a simvastatin medication other fibrates with simvastatin, as these agents can cause myopathy when given alone and the risk is increased when they are coadministered Cases of myopathy, including rhabdomyolysis, have been reported with simvastatin coadministered with colchicine, and caution should be exercised when prescribing simvastatin with colchicine 12. Professor Michael Murray - The University of Sydney Simvastatin significantly decreased plasma levels of LDL-C, TG, and Apo B.
Results from the extension at 48 weeks were comparable to those observed in the base study.
Be sure to ask your doctor about anything you do not understand. Your doctor will give you instructions about diet, exercise, testing your blood sugar, and adjusting your dose when you are sick. It is very important that you read and understand this information.
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CHD alone; or peripheral vascular disease, cerebrovascular disease, diabetes or treated hypertension, with or without CHD what is a simvastatin medication, age, creatinine levels up to the entry limit of 2.
There were cataracts in female rats after two years of treatment with 50 and 100 mg/kg/day 22 and 25 times the human AUC at 80 mg/day, respectively what is a simvastatin medication in dogs after three months at 90 mg/kg/day 19 times and at two years at 50 mg/kg/day 5 times The HPS results showed that ZOCOR 40 mg/day significantly reduced: total and CHD mortality; non-fatal MI, stroke, and revascularization procedures coronary and non-coronary see Table 4 Two composite endpoints were defined in order to have sufficient events to assess relative risk reductions across a range of baseline characteristics see Figure 1 What is a simvastatin medication composite of major coronary events MCE was comprised of CHD mortality and non-fatal MI analyzed by time-to-first event; 898 patients treated with ZOCOR had events and 1, 12 patients on placebo had events A composite of major vascular events MVE was comprised of MCE, stroke and revascularization procedures including coronary, peripheral and other non-coronary procedures analyzed by time-to-first event; 2, 33 patients treated with ZOCOR had events and 2, 85 patients on placebo had events Significant relative risk reductions were observed for both composite endpoints 27% for MCE and 24% for MVE, p 0.
001 Treatment with ZOCOR produced significant relative risk reductions for all components of the composite endpoints. The risk reductions produced by ZOCOR in both MCE and MVE were evident and consistent regardless of cardiovascular disease related medical history at study entry i.
Serum cholesterol concentration and coronary heart disease in population with low cholesterol concentrations, lipitor hypoglycemia. Report of the Conference on Low Blood Cholesterol: Mortality Associations.
de Lemos What is simvastatin medicine, Blazing MA, Wiviott SD, Lewis EF, Fox KA, White HD, Rouleau JL, Pedersen TR, Gardner LH, Mukherjee R, Ramsey KE, Palmisano J, Bilheimer DW, Pfeffer MA, Califf RM, Braunwald E: Early intensive vs a delayed conservative simvastatin strategy in what is simvastatin medicine with acute coronary syndromes: phase Z of the A to Z trial.
Jacobs D, Blackburn H, Higgins M, Reed D, Iso H, McMillan G, Neaton J, Nelson J, Potter J, Rifkind B, et al.
|Simvastatin 10 mg uses 2% for patients on 20 mg/day.||With other statins, clinically evident bleeding and/or increased prothrombin time has been reported in a few patients taking coumarin anticoagulants concomitantly. what is simvastatin medicine|
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Simvastatin 10 mg uses
In a placebo-controlled, 12-week study there was no significant effect of Simvastatin 80 mg on the plasma testosterone response to human chorionic gonadotropin. In another 24-week study, Simvastatin 20 to 40 mg had no detectable effect on spermatogenesis. In clinical studies, Simvastatin did not impair adrenal reserve or significantly reduce simvastatin 10 mg uses plasma cortisol concentration. Small reductions from baseline in basal plasma testosterone in men were observed in clinical studies with Simvastatin, an effect also observed with other statins and the bile acid sequestrant cholestyramine.
There was no effect on plasma gonadotropin levels. simvastatin 10 mg uses
Breast-feeding: It is not known ifsimvastatin passes into breast milk. It may simvastatin 10 mg uses harm to the unborn baby. If youbecome pregnant, stop taking this medication and contact your doctorimmediately.
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Common adverse effects in italic, life-threatening effects underlined; generic names in bold; classifications in SMALL CAPS; Canadian drug name; Prototype drugThe warning from the Medicines and Healthcare products Regulatory Agency - issued in its August drug safety update - changes the dosage recommendations for simvastatin, with those patients taking the cholesterol-lowering drug in conjunction with diltiazem or amlodipine to only be given the maximum dose of 20mg what is simvastatin medicine day.
Report unexplained muscle pain, tenderness, or weakness, especially if accompanied by malaise or fever, to physician. The latest update from what is simvastatin medicine agency also warns that simvastin is now also contraindicated with ciclosporin, danazol and gemfibrozil. The changes come after the MHRA issued a warning in May 2010 about the increased risk of myopathy which was associated with the use of high-dose simvastatin of 80mg a day.
Report signs of bleeding to physician promptly when taking concurrent warfarin.
Shawn E. Powell, BS, MS, DDS | Office of the President ...; Price U, Le HO, Powell SE, Schmid MJ, Marx DB, Zhang Y, Wang D, Narayana N, Reinhardt RA: Effects of local Simvastatin -alendronate conjugate in preventing ...
Adherence to lifestyle modifications and to statin therapy are required for atherosclerotic cardiovascular disease ASCVD risk reduction and, thus, should what is simvastatin used for uk reinforced periodically.
Dosage of simvastatin must be carefully adjusted according to individual requirements and response. The ACC/AHA guideline for management of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults states that lipoprotein concentrations should be determined within 4-12 weeks following initiation of statin therapy to determine the patient's response to therapy and adherence and monitored every 3-12 months thereafter as clinically indicated.
240 mL of grapefruit juice may be acceptable. The manufacturers state that serum lipoprotein concentrations should be determined 4 weeks after initiation of simvastatin monotherapy or 2 or what is simvastatin used for uk weeks after initiation or titration of therapy with the fixed-combination preparation Vytorin and then periodically thereafter.
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Terms & conditions
Terms and Conditions - IV drugs: an IV catheter is placed for safe administration of the drug.
Does simvastatin cause increased urination?
Concomitant food intake does not affect the absorption. The availability of the beta-hydroxyacid to the systemic circulation following an oral dose of simvastatin was found to be less than 5% of the dose. Maximum plasma concentration of active inhibitors is reached approximately 1-2 hours what is simvastatin medicine administration of simvastatin.
Does simvastatin cause reflux?
Minor statin side effects that have been reported by some individuals include: Many of these side effects are mild and will dissipate as your body gets used to taking the medication. It is therefore crucial to report symptoms including: Patients with diabetes must also monitor closely for increased hunger, thirst, and urination, fruit-like breath odor, sweating, or changes in what is simvastatin used for uk level of consciousness.
Simvastatin Zocor is approved for different specific cholesterol disorders including: And several other disorders your provider will help you understand what type of cholesterol problem you have and the best way to treat it Simvastatin Zocor and other statin drugs have a generally safe drug profile, meaning they are well tolerated by most patients. Additionally, there are some more serious adverse effects that should what is simvastatin used for uk reported to your provider immediately if they occur: Any changes that indicate liver problems, including yellowing of skin or eyes Muscle problems are a side effect that can range from mild to life threatening.
Is simvastatin a generic drug?
In the Scandinavian Simvastatin Survival Study 4S therapy with simvastatin in 4444 patients with hypercholesterolemia and angina pectoris or prior MI was associated with reductions in total mortality 30% CHD mortality 42% and hospital-verified nonfatal MI 37% compared with placebo over a median of 5.
Several clinical trials designed to evaluate the benefits of simvastatin in patients with established CHD have reported what is simvastatin medicine in the risk of cardiovascular events, as evidenced by reductions in the risks of total mortality and nonfatal coronary events.
Does simvastatin cause memory loss?
As mentioned earlier, rosuvastatin what is simvastatin medicine far fewer harmful drug interactions Cyclosporine can exponentially increase rosuvastatin levels in the blood, increasing the chances of side effects. Therapy usually is initiated with 10 or 20 mg daily, but individuals who have a high restricted to patients who have been taking simvastatin 80 mg chronically for example, for 12 months or more without evidence of muscle toxicity because the 80 mg dose is associated with increased risk of muscle toxicity, including simvastatin who need to start an what is simvastatin medicine drug that should not be taken with simvastatin or is associated with a dose cap for simvastatin should be switched to an alternative statin or statin-based regimen with less potential for the The maximum dose is 40 mg daily, and this dose should be reserved for patients who do not adequately respond to a 20 mg dose.
How does grapefruit affect simvastatin?
Your doctor may conduct liver function tests when using statins to monitor liver enzymes and other liver function. Consult your doctor for more details. This drug maybe used to treat other diseases and conditions. In addition to eating what is a simvastatin medication proper diet such as a low-cholesterol/low-fat diet other lifestyle changes that may help simvastatin medication work better include exercising, losing weight if overweight, and stopping smoking.
Para que se usa simvastatin 10 mg?
The risk of this occurring is increased when taking certain types of medication or consuming larger quantities of grapefruit juice. All patients starting therapy with simvastatin should be advised of the risk of myopathy and told to report promptly any unexplained muscle pain, tenderness or weakness.
Is livalo the same as simvastatin?
Simvastatin has been administered to a limited number of hypercholesterolemic children and adolescents without apparent adverse effects. When simvastatin is used in fixed combination with ezetimibe, the what is simvastatin medicine cautions, precautions, and contraindications associated with ezetimibe must be considered in addition to those associated with simvastatin.
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There was no evidence of genotoxicity at doses up to 600 mg/kg with the combination of ezetimibe and simvastatin 1: in the in vivo mouse micronucleus test. No evidence of clastogenicity was observed in vitro in a chromosomal aberration assay in human peripheral blood lymphocytes with ezetimibe and simvastatin with or without metabolic activation.
Is there a generic version of ezetimibe and simvastatin?
These are to measure your lipid levels and also to check that your liver has source been affected by taking simvastatin. our what is simvastatin used for uk will give you advice about eating a healthy diet, cutting down on the amount of alcohol you normally drink, reducing the amount of salt in your diet, stopping smoking and taking regular exercise.
You will need to have some blood tests from time to time.
Why must simvastatin be taken at night?
Multum's drug information is an informational resource designed to assist licensed healthcare practitioners simvastatin 10 mg uses caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is simvastatin 10 mg uses, effective or appropriate for any given patient.
Multum's drug information does not endorse drugs, diagnose patients or recommend therapy.
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Product evaluations simvastatin; 5 counts:
Your doctor may start you on a low dose of simvastatin and gradually increase your dose. Many statins what is a simvastatin medication been detected in human breast milk. Simvastatin comes in tablet form and is given once a day at bedtime, with or without food. The importance of the drug to the mother should be considered.
Because of the possibility for adverse reactions in nursing infants from simvastatin, what is a simvastatin medication choice should be made whether to stop nursing or to stop use of this medication. Take simvastatin exactly as prescribed.
What is a simvastatin medication et your doctor know immediately if you have unexplained muscle pain, tenderness, or weakness during treatment, especially if these what is a simvastatin medication are accompanied by fever or dark colored urine. ou should avoid the consumption of grapefruit or grapefruit juice during treatment with simvastatin.
Mg/dL range: 64. mg/dL in the Simvastatin 40 mg group compared to 207. After 24 weeks of treatment, the mean achieved LDL-C value was 124. Simvastatin significantly decreased plasma levels of LDL-C, TG, what is a simvastatin medication Apo B. Results from the extension at 48 weeks were comparable to those observed in the base study.
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La informaci n detallada y actualizada de este medicamento est disponible en la p gina Web de la Agencia Espa ola de Medicamentos y Productos Sanitarios AEMPS ww. Simvastatina Pensa 20 what is simvastatin medicine comprimidos recubiertos con pel cula EFG: Envase con 28 comprimidos. Simvastatina Pensa 40 mg comprimidos recubiertos con pel cula EFG: Envase con 28 comprimidos.
What is simvastatin medicine 001 Rhabdomyolysis developed in 0. In the SEARCH trial, which compared the safety and efficacy of simvastatin 80 mg what is simvastatin medicine 20 mg in patients surviving myocardial infarction, myopathy developed in 0. I. P 0. of the patients receiving the 80 mg dose versus only 0. 3 of those receiving the 20 mg dose relative risk.