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Isotretinoin capsules buy adverse reactions reported in clinical trials were reversible when therapy was discontinued; however, some persisted after cessation of therapy colitis, esophagitis/esophageal ulceration, ileitis, nausea, other nonspecific anemia, thrombocytopenia, related home page rare reports of agranulocytosis see PATIENT INFORMATION See PRECAUTIONS: Laboratory Tests for ligaments, premature epiphyseal closure, decreases in bone mineral density see WARNINGS: Skeletal musculoskeletal symptoms sometimes severe including back pain, myalgia, and arthralgia see PATIENT INFORMATION transient pain in the chest see PATIENT INFORMATION arthritis, tendonitis, other types of bone abnormalities, elevations of CPK/rare reports of rhabdomyolysis see PRECAUTIONS: Laboratory the depression subsided with discontinuation of therapy and recurred with bruising, cheilitis dry lips dry mouth, dry nose, dry skin, epistaxis, skin, hair abnormalities, hirsutism, hyperpigmentation and hypopigmentation, infections including disseminated herpes simplex nail dystrophy, paronychia, pruritus, pyogenic granuloma, rash including facial erythema, seborrhea, and eczema Stevens-Johnson syndrome, sunburn susceptibility increased, sweating, toxic epidermal necrolysis, urticaria, vasculitis including Wegener's granulomatosis; delayed isotretinoin capsules buy or exuberant granulation tissue with crusting; see PATIENT INFORMATION conjunctivitis, dry eyes, eyelid inflammation, keratitis, optic neuritis, decrease in serum high-density lipoprotein HDL levels, elevations of serum white blood cell counts including severe neutropenia and rare isotretinoin capsules buy of with isotretinoin 13-cis-retinoic acid Arch Dermatol 116: 51.

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Isotretinoin
Clinical data
PronunciationSee note at tretinoin
Trade namesAccutane (originator), others [1]
AHFS/Drugs.comMonograph
MedlinePlusa681043
License dataUS   FDA: Isotretinoin
Pregnancy categoryAU: X (High risk) US: X (Contraindicated)
Routes of administrationBy mouth, topical
ATC codeD10AD04 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only)
Pharmacokinetic data
BioavailabilityVariable
Protein binding99.9%
MetabolismHepatic
Elimination half-life10–20 hours
ExcretionRenal and fecal

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